Genomic Nanoprocessors

The interface of genomics and electronic engineering research is an exciting new area which promises to yield imaginative approaches to the development of medical devices and diagnostics. DNA molecules have found use as combinatorial computers, proto-transistors and semi-conductors amongst other things. However, the potential for integrating together, on a single semiconductor device, biomolecule-based equivalents of electronics circuit elements is untapped at present.

Future Deliverable
The potential position of leadership which could be created for the UK with respect to exploitation of genomics-based technologies

The core scientific understanding and technology underlying this radical vision are being addressed through the Beacon Project being undertaken by Professor Peter Ghazal and colleagues at the University of Edinburgh. Four leading centres of expertise in biotechnology, electronic engineering, chemistry and physics have been brought together to develop a platform technology in genomic nanoprocessors.

Early Achievement
Scottish Enterprise is funding an industrial PhD studentship to facilitate a collaboration with a Scottish microelectronics company.

Healthcare Deliverables

  • a radical new vision of future healthcare, known as ‘bio-intelligent medication’
  • nano-scale devices administered in vivo to detect and prevent disease.

The team is investigating technology based upon the idea of using DNA molecules, anchored to a silicon substrate, which switch between two configurations in response to electronic and biochemical signals, in a way that mimics transistor-like behaviour. A key innovative feature of the project will be the integration of these devices within digital circuitry to provide on-chip intelligence (sensing, logic and read/write elements for example) for local data processing.

A core project patent covering fundamental aspects of the work has been submitted and will be published in Spring 2004.

Potential Applications for the hybrid ‘DNA on silicon’ processors

  • Medical Devices
  • Diagnostics

The long-term vision of the team is to apply this technology to biointelligent medication will ultimately be dependent upon the ability to eliminate the inorganic silicon substrate from the processors to leave devices which are purely bio-organic and can therefore be administered in vivo

Industry Interaction
As a result of the collaboration between the four research centres, a contract from a major Japanese microelectronics company has been secured

Intellectual property (IP) management during the project has been identified as a crucial aspect of the programme, and a substantial portfolio of protected and commercialisable IP could be generated both from the core technology under development and as spin-off opportunities.

Significant Achievement
Close scientific collaboration has already identified new surface chemistries suitable for the interface between electronic circuits and biological molecules

For further details on this project please see the project website or contact the team leader Professor Peter Ghazal Scottish Centre for Genomic Technology and Informatics, University of Edinburgh, email: Tel: 0131 650 1000

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